1aa7
From Proteopedia
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| - | [[Image:1aa7.gif|left|200px]] | + | [[Image:1aa7.gif|left|200px]] |
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| - | '''INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0''' | + | {{Structure |
| + | |PDB= 1aa7 |SIZE=350|CAPTION= <scene name='initialview01'>1aa7</scene>, resolution 2.08Å | ||
| + | |SITE= <scene name='pdbsite=S1:RNA-Binding+Site'>S1</scene> | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AA7 is a [ | + | 1AA7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AA7 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1., Sha B, Luo M, Nat Struct Biol. 1997 Mar;4(3):239-44. PMID:[http:// | + | Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1., Sha B, Luo M, Nat Struct Biol. 1997 Mar;4(3):239-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9164466 9164466] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Unidentified influenza virus]] | [[Category: Unidentified influenza virus]] | ||
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[[Category: virion budding]] | [[Category: virion budding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:55:03 2008'' |
Revision as of 07:55, 20 March 2008
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| , resolution 2.08Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
INFLUENZA VIRUS MATRIX PROTEIN CRYSTAL STRUCTURE AT PH 4.0
Overview
Matrix protein (M1) of influenza virus is a bifunctional protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously. The X-ray crystal structure of the N-terminal portion of type A influenza virus M1-amino acid residues 2-158-has been determined at 2.08 A resolution at pH 4.0. The protein forms a dimer. A highly positively charged region on the dimer surface is suitably positioned to bind RNA while the hydrophobic surface opposite the RNA binding region may be involved in interactions with the membrane. The membrane-binding hydrophobic surface could be buried or exposed after a conformational change.
About this Structure
1AA7 is a Single protein structure of sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.
Reference
Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1., Sha B, Luo M, Nat Struct Biol. 1997 Mar;4(3):239-44. PMID:9164466
Page seeded by OCA on Thu Mar 20 09:55:03 2008
