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1ad6
From Proteopedia
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| - | [[Image:1ad6.gif|left|200px]] | + | [[Image:1ad6.gif|left|200px]] |
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| - | '''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR''' | + | {{Structure |
| + | |PDB= 1ad6 |SIZE=350|CAPTION= <scene name='initialview01'>1ad6</scene>, resolution 2.3Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AD6 is a [ | + | 1AD6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:[http:// | + | Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9145110 9145110] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tumor suppressor]] | [[Category: tumor suppressor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:55:55 2008'' |
Revision as of 07:55, 20 March 2008
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| , resolution 2.3Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR
Contents |
Overview
The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
Disease
Known diseases associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]
About this Structure
1AD6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110
Page seeded by OCA on Thu Mar 20 09:55:55 2008
