1ad6

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[[Image:1ad6.gif|left|200px]]<br /><applet load="1ad6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ad6.gif|left|200px]]
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caption="1ad6, resolution 2.3&Aring;" />
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'''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''<br />
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{{Structure
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|PDB= 1ad6 |SIZE=350|CAPTION= <scene name='initialview01'>1ad6</scene>, resolution 2.3&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1AD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA].
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1AD6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA].
==Reference==
==Reference==
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Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9145110 9145110]
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Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9145110 9145110]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tumor suppressor]]
[[Category: tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:43:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:55:55 2008''

Revision as of 07:55, 20 March 2008

Image:1ad6.gif


PDB ID 1ad6

Drag the structure with the mouse to rotate
, resolution 2.3Å
Coordinates: save as pdb, mmCIF, xml



DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR


Contents

Overview

The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.

Disease

Known diseases associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]

About this Structure

1AD6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110

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