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2wgx

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==About this Structure==
==About this Structure==
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[[2wgx]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGX OCA].
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[[2wgx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGX OCA].
==See Also==
==See Also==

Revision as of 05:40, 20 October 2012

Image:2wgx.png

Template:STRUCTURE 2wgx

Contents

HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D

Template:ABSTRACT PUBMED 19515728

About this Structure

2wgx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Khoo KH, Joerger AC, Freund SM, Fersht AR. Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core. Protein Eng Des Sel. 2009 Jul;22(7):421-30. Epub 2009 Jun 10. PMID:19515728 doi:10.1093/protein/gzp018
  • Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200

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