1aol

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[[Image:1aol.gif|left|200px]]<br /><applet load="1aol" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1aol.gif|left|200px]]
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caption="1aol, resolution 2.0&Aring;" />
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'''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN'''<br />
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{{Structure
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|PDB= 1aol |SIZE=350|CAPTION= <scene name='initialview01'>1aol</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1AOL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Friend_murine_leukemia_virus Friend murine leukemia virus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOL OCA].
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1AOL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Friend_murine_leukemia_virus Friend murine leukemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOL OCA].
==Reference==
==Reference==
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Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9287219 9287219]
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Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9287219 9287219]
[[Category: Friend murine leukemia virus]]
[[Category: Friend murine leukemia virus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: viral glycoprotein]]
[[Category: viral glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:00:24 2008''

Revision as of 08:00, 20 March 2008

Image:1aol.gif


PDB ID 1aol

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN


Overview

An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.

About this Structure

1AOL is a Single protein structure of sequence from Friend murine leukemia virus. Full crystallographic information is available from OCA.

Reference

Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:9287219

Page seeded by OCA on Thu Mar 20 10:00:24 2008

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