1gk4
From Proteopedia
(New page: 200px<br /> <applet load="1gk4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gk4, resolution 2.30Å" /> '''HUMAN VIMENTIN COIL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GK4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GK4 OCA]]. | + | 1GK4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: STA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GK4 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: stutter]] | [[Category: stutter]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:28:42 2007'' |
Revision as of 06:24, 30 October 2007
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HUMAN VIMENTIN COIL 2B FRAGMENT (CYS2)
Overview
Intermediate filaments (IFs) are key components of the cytoskeleton in, higher eukaryotic cells. The elementary IF 'building block' is an, elongated coiled-coil dimer consisting of four consecutive alpha-helical, segments. The segments 1A and 2B include highly conserved sequences and, are critically involved in IF assembly. Based on the crystal structures of, three human vimentin fragments at 1.4-2.3 A resolution (PDB entries 1gk4, 1gk6 and 1gk7), we have established the molecular organization of these, two segments. The fragment corresponding to segment 1A forms a single, amphipatic alpha-helix, which is compatible with a coiled-coil geometry., While this segment might yield a coiled coil within an isolated dimer, monomeric 1A helices are likely to play a role in specific dimer-dimer, ... [(full description)]
About this Structure
1GK4 is a [Single protein] structure of sequence from [Homo sapiens] with ACT as [ligand]. Structure known Active Site: STA. Full crystallographic information is available from [OCA].
Reference
Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly., Strelkov SV, Herrmann H, Geisler N, Wedig T, Zimbelmann R, Aebi U, Burkhard P, EMBO J. 2002 Mar 15;21(6):1255-66. PMID:11889032
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