1b03
From Proteopedia
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| - | [[Image:1b03.gif|left|200px]] | + | [[Image:1b03.gif|left|200px]] |
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| - | '''SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE''' | + | {{Structure |
| + | |PDB= 1b03 |SIZE=350|CAPTION= <scene name='initialview01'>1b03</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1B03 is a [ | + | 1B03 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA]. |
==Reference== | ==Reference== | ||
| - | A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide., Tugarinov V, Zvi A, Levy R, Anglister J, Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:[http:// | + | A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide., Tugarinov V, Zvi A, Levy R, Anglister J, Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201400 10201400] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Anglister, J.]] | [[Category: Anglister, J.]] | ||
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[[Category: p1053 structure]] | [[Category: p1053 structure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:04:30 2008'' |
Revision as of 08:04, 20 March 2008
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SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE
Overview
The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.
About this Structure
1B03 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide., Tugarinov V, Zvi A, Levy R, Anglister J, Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:10201400
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