3e8r

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Revision as of 15:03, 25 July 2012

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Template:STRUCTURE 3e8r

Contents 1 Crystal structure of catalytic domain of TACE with hydroxamate inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal structure of catalytic domain of TACE with hydroxamate inhibitor

Template:ABSTRACT PUBMED 18835710

About this Structure

3e8r is a 2 chain structure of A Disintegrin And Metalloproteinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• A Disintegrin And Metalloproteinase

Reference

• Mazzola RD Jr, Zhu Z, Sinning L, McKittrick B, Lavey B, Spitler J, Kozlowski J, Neng-Yang S, Zhou G, Guo Z, Orth P, Madison V, Sun J, Lundell D, Niu X. Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5809-14. Epub 2008 Sep 13. PMID:18835710 doi:10.1016/j.bmcl.2008.09.045