1bmp
From Proteopedia
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| - | [[Image:1bmp.gif|left|200px]] | + | [[Image:1bmp.gif|left|200px]] |
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| - | '''BONE MORPHOGENETIC PROTEIN-7''' | + | {{Structure |
| + | |PDB= 1bmp |SIZE=350|CAPTION= <scene name='initialview01'>1bmp</scene>, resolution 2.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= HOP-1 CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''BONE MORPHOGENETIC PROTEIN-7''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BMP is a [ | + | 1BMP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMP OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:[http:// | + | Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8570652 8570652] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transforming growth factor]] | [[Category: transforming growth factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:13:03 2008'' |
Revision as of 08:13, 20 March 2008
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| , resolution 2.8Å | |||||||
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| Gene: | HOP-1 CDNA (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BONE MORPHOGENETIC PROTEIN-7
Overview
We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
About this Structure
1BMP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:8570652
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