1bnl

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[[Image:1bnl.gif|left|200px]]<br /><applet load="1bnl" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1bnl.gif|left|200px]]
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caption="1bnl, resolution 2.9&Aring;" />
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'''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''<br />
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{{Structure
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|PDB= 1bnl |SIZE=350|CAPTION= <scene name='initialview01'>1bnl</scene>, resolution 2.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE= COLLAGEN XVIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1BNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNL OCA].
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1BNL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNL OCA].
==Reference==
==Reference==
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Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9724722 9724722]
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Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9724722 9724722]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc]]
[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:57:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:13:21 2008''

Revision as of 08:13, 20 March 2008

Image:1bnl.gif


PDB ID 1bnl

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands:
Gene: COLLAGEN XVIII (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN


Contents

Overview

The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and murine endostatin in solution. The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. The N-terminal loop ordered around the zinc makes a dimeric contact in human endostatin crystals. The location of the zinc site at the amino terminus, immediately adjacent to the precursor cleavage site, suggests the possibility that the zinc may be involved in activation of the antiangiogenic activity following cleavage from the inactive collagen XVIII precursor or in the cleavage process itself.

Disease

Known disease associated with this structure: Knobloch syndrome OMIM:[120328]

About this Structure

1BNL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:9724722

Page seeded by OCA on Thu Mar 20 10:13:21 2008

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