1bv1
From Proteopedia
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| - | [[Image:1bv1.gif|left|200px]] | + | [[Image:1bv1.gif|left|200px]] |
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| - | '''BIRCH POLLEN ALLERGEN BET V 1''' | + | {{Structure |
| + | |PDB= 1bv1 |SIZE=350|CAPTION= <scene name='initialview01'>1bv1</scene>, resolution 2.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= BET V 1 1.2801 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3505 Betula pendula]) | ||
| + | }} | ||
| + | |||
| + | '''BIRCH POLLEN ALLERGEN BET V 1''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BV1 is a [ | + | 1BV1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV1 OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy., Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD, Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:[http:// | + | X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy., Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD, Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8946858 8946858] |
[[Category: Betula pendula]] | [[Category: Betula pendula]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: pathogenesis-related protein]] | [[Category: pathogenesis-related protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:16:09 2008'' |
Revision as of 08:16, 20 March 2008
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| , resolution 2.0Å | |||||||
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| Gene: | BET V 1 1.2801 (Betula pendula) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BIRCH POLLEN ALLERGEN BET V 1
Overview
The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.
About this Structure
1BV1 is a Single protein structure of sequence from Betula pendula. Full crystallographic information is available from OCA.
Reference
X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy., Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD, Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:8946858
Page seeded by OCA on Thu Mar 20 10:16:09 2008
