1bvj
From Proteopedia
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| - | [[Image:1bvj.gif|left|200px]] | + | [[Image:1bvj.gif|left|200px]] |
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| - | '''HIV-1 RNA A-RICH HAIRPIN LOOP''' | + | {{Structure |
| + | |PDB= 1bvj |SIZE=350|CAPTION= <scene name='initialview01'>1bvj</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''HIV-1 RNA A-RICH HAIRPIN LOOP''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BVJ is a [ | + | 1BVJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hevea Hevea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVJ OCA]. |
==Reference== | ==Reference== | ||
| - | HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:[http:// | + | HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9846871 9846871] |
[[Category: Hevea]] | [[Category: Hevea]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: rna hairpin loop]] | [[Category: rna hairpin loop]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:16:19 2008'' |
Revision as of 08:16, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
HIV-1 RNA A-RICH HAIRPIN LOOP
Overview
Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.
About this Structure
1BVJ is a Single protein structure of sequence from Hevea. Full crystallographic information is available from OCA.
Reference
HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:9846871
Page seeded by OCA on Thu Mar 20 10:16:19 2008
