1bvk

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[[Image:1bvk.gif|left|200px]]<br /><applet load="1bvk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1bvk.gif|left|200px]]
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caption="1bvk, resolution 2.7&Aring;" />
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'''HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME'''<br />
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{{Structure
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|PDB= 1bvk |SIZE=350|CAPTION= <scene name='initialview01'>1bvk</scene>, resolution 2.7&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]
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|GENE=
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}}
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'''HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1BVK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVK OCA].
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1BVK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BVK OCA].
==Reference==
==Reference==
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Conformational correction mechanisms aiding antigen recognition by a humanized antibody., Holmes MA, Buss TN, Foote J, J Exp Med. 1998 Feb 16;187(4):479-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9463398 9463398]
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Conformational correction mechanisms aiding antigen recognition by a humanized antibody., Holmes MA, Buss TN, Foote J, J Exp Med. 1998 Feb 16;187(4):479-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9463398 9463398]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: humanized antibody]]
[[Category: humanized antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:16:18 2008''

Revision as of 08:16, 20 March 2008

Image:1bvk.gif


PDB ID 1bvk

Drag the structure with the mouse to rotate
, resolution 2.7Å
Activity: Lysozyme, with EC number 3.2.1.17
Coordinates: save as pdb, mmCIF, xml



HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME


Overview

The crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-A resolution. The structure of the antigen combining site in the complex is nearly identical to that of the complexed form of the parent mouse antibody, D1.3. In contrast, the combining sites of the unliganded mouse and humanized antilysozymes show moderate conformational differences. This disparity suggests that a conformational readjustment process linked to antigen binding reverses adverse conformations in the complementarity determining regions that had been introduced by engineering these segments next to human framework regions in the humanized antibody.

About this Structure

1BVK is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformational correction mechanisms aiding antigen recognition by a humanized antibody., Holmes MA, Buss TN, Foote J, J Exp Med. 1998 Feb 16;187(4):479-85. PMID:9463398

Page seeded by OCA on Thu Mar 20 10:16:18 2008

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