1c4p

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[[Image:1c4p.gif|left|200px]]<br /><applet load="1c4p" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1c4p.gif|left|200px]]
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caption="1c4p, resolution 2.4&Aring;" />
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'''BETA DOMAIN OF STREPTOKINASE'''<br />
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{{Structure
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|PDB= 1c4p |SIZE=350|CAPTION= <scene name='initialview01'>1c4p</scene>, resolution 2.4&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''BETA DOMAIN OF STREPTOKINASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1C4P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].
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1C4P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].
==Reference==
==Reference==
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Crystal structure of streptokinase beta-domain., Wang X, Tang J, Hunter B, Zhang XC, FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10508922 10508922]
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Crystal structure of streptokinase beta-domain., Wang X, Tang J, Hunter B, Zhang XC, FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10508922 10508922]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptococcus dysgalactiae subsp. equisimilis]]
[[Category: Streptococcus dysgalactiae subsp. equisimilis]]
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[[Category: plasminogen activator]]
[[Category: plasminogen activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:02:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:19:45 2008''

Revision as of 08:19, 20 March 2008

Image:1c4p.gif


PDB ID 1c4p

Drag the structure with the mouse to rotate
, resolution 2.4Å
Coordinates: save as pdb, mmCIF, xml



BETA DOMAIN OF STREPTOKINASE


Overview

Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.

About this Structure

1C4P is a Single protein structure of sequence from Streptococcus dysgalactiae subsp. equisimilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of streptokinase beta-domain., Wang X, Tang J, Hunter B, Zhang XC, FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:10508922

Page seeded by OCA on Thu Mar 20 10:19:45 2008

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