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1cd9
From Proteopedia
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| - | [[Image:1cd9.gif|left|200px]] | + | [[Image:1cd9.gif|left|200px]] |
| - | + | ||
| - | '''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR''' | + | {{Structure |
| + | |PDB= 1cd9 |SIZE=350|CAPTION= <scene name='initialview01'>1cd9</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CD9 is a [ | + | 1CD9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD9 OCA]. |
==Reference== | ==Reference== | ||
| - | Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:[http:// | + | Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10537111 10537111] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:22:55 2008'' |
Revision as of 08:23, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
Overview
Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
About this Structure
1CD9 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111
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