1cma

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[[Image:1cma.jpg|left|200px]]<br /><applet load="1cma" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1cma.jpg|left|200px]]
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caption="1cma, resolution 2.800&Aring;" />
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'''MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE'''<br />
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{{Structure
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|PDB= 1cma |SIZE=350|CAPTION= <scene name='initialview01'>1cma</scene>, resolution 2.800&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1CMA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SAM:'>SAM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMA OCA].
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1CMA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMA OCA].
==Reference==
==Reference==
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Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands., Somers WS, Phillips SE, Nature. 1992 Oct 1;359(6394):387-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1406951 1406951]
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Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands., Somers WS, Phillips SE, Nature. 1992 Oct 1;359(6394):387-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1406951 1406951]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein-dna complex]]
[[Category: protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:26:09 2008''

Revision as of 08:26, 20 March 2008


PDB ID 1cma

Drag the structure with the mouse to rotate
, resolution 2.800Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE


Overview

The crystal structure of the met repressor-operator complex shows two dimeric repressor molecules bound to adjacent sites 8 base pairs apart on an 18-base-pair DNA fragment. Sequence specificity is achieved by insertion of double-stranded antiparallel protein beta-ribbons into the major groove of B-form DNA, with direct hydrogen-bonding between amino-acid side chains and the base pairs. The repressor also recognizes sequence-dependent distortion or flexibility of the operator phosphate backbone, conferring specificity even for inaccessible base pairs.

About this Structure

1CMA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands., Somers WS, Phillips SE, Nature. 1992 Oct 1;359(6394):387-93. PMID:1406951

Page seeded by OCA on Thu Mar 20 10:26:09 2008

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