1cmi

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[[Image:1cmi.gif|left|200px]]<br /><applet load="1cmi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1cmi.gif|left|200px]]
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caption="1cmi, resolution 2.5&Aring;" />
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'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE'''<br />
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{{Structure
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|PDB= 1cmi |SIZE=350|CAPTION= <scene name='initialview01'>1cmi</scene>, resolution 2.5&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1CMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA].
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1CMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA].
==Reference==
==Reference==
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Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10426949 10426949]
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Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10426949 10426949]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: dynein light chain]]
[[Category: dynein light chain]]
[[Category: lc8]]
[[Category: lc8]]
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[[Category: nnos]]
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[[Category: nno]]
[[Category: pin]]
[[Category: pin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:26:12 2008''

Revision as of 08:26, 20 March 2008

Image:1cmi.gif


PDB ID 1cmi

Drag the structure with the mouse to rotate
, resolution 2.5Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE


Contents

Overview

The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.

Disease

Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[604258], Esophageal cancer OMIM:[604050], Lung cancer OMIM:[604050]

About this Structure

1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from OCA.

Reference

Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949

Page seeded by OCA on Thu Mar 20 10:26:12 2008

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