1cok
From Proteopedia
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| - | [[Image:1cok.gif|left|200px]] | + | [[Image:1cok.gif|left|200px]] |
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| - | '''STRUCTURE OF THE C-TERMINAL DOMAIN OF P73''' | + | {{Structure |
| + | |PDB= 1cok |SIZE=350|CAPTION= <scene name='initialview01'>1cok</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''STRUCTURE OF THE C-TERMINAL DOMAIN OF P73''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1COK is a [ | + | 1COK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COK OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:[http:// | + | Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10449409 10449409] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: p73 sam-like domain]] | [[Category: p73 sam-like domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:26:55 2008'' |
Revision as of 08:26, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE C-TERMINAL DOMAIN OF P73
Contents |
Overview
p73 and p63 are two recently cloned genes with homology to the tumor suppressor p53, whose protein product is a key transcriptional regulator of genes involved in cell cycle arrest and apoptosis. While all three proteins share conserved transcriptional activation, DNA-binding and oligomerization domains, p73 and p63 have an additional conserved C-terminal region. We have determined the three-dimensional solution structure of this conserved C-terminal domain of human p73. The structure reveals a small five-helix bundle with striking similarity to the SAM (sterile alpha motif) domains of two ephrin receptor tyrosine kinases. The SAM domain is a putative protein-protein interaction domain found in a variety of cytoplasmic signaling proteins and has been shown to form both homo- and hetero-oligomers. However, the SAM-like C-terminal domains of p73 and p63 are monomeric and do not interact with one another, suggesting that this domain may interact with additional, as yet uncharacterized proteins in a signaling and/or regulatory role.
Disease
Known disease associated with this structure: Neuroblastoma (1) OMIM:[601990]
About this Structure
1COK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain., Chi SW, Ayed A, Arrowsmith CH, EMBO J. 1999 Aug 16;18(16):4438-45. PMID:10449409
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