1csg
From Proteopedia
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| - | [[Image:1csg.gif|left|200px]] | + | [[Image:1csg.gif|left|200px]] |
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| - | '''THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR''' | + | {{Structure |
| + | |PDB= 1csg |SIZE=350|CAPTION= <scene name='initialview01'>1csg</scene>, resolution 2.7Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CSG is a [ | + | 1CSG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSG OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor., Walter MR, Cook WJ, Ealick SE, Nagabhushan TL, Trotta PP, Bugg CE, J Mol Biol. 1992 Apr 20;224(4):1075-85. PMID:[http:// | + | Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor., Walter MR, Cook WJ, Ealick SE, Nagabhushan TL, Trotta PP, Bugg CE, J Mol Biol. 1992 Apr 20;224(4):1075-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1569568 1569568] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cytokine]] | [[Category: cytokine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:28:21 2008'' |
Revision as of 08:28, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Contents |
Overview
The crystal structure of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) has been determined at 2.8 A resolution using multiple isomorphous replacement techniques. There are two molecules in the crystallographic asymmetric unit, which are related by an approximate non-crystallographic 2-fold axis. The overall structure is highly compact and globular with a predominantly hydrophobic core. The main structural feature of rhGM-CSF is a four alpha-helix bundle, which represents approximately 42% of the structure. The helices are arranged in a left-handed antiparallel bundle with two overhand connections. Within the connections is a two-stranded antiparallel beta-sheet. The tertiary structure of rhGM-CSF has a topology similar to that of porcine growth factor and interferon-beta. Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus.
Disease
Known disease associated with this structure: Leukemia, acute myeloid, M2 type OMIM:[306250]
About this Structure
1CSG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor., Walter MR, Cook WJ, Ealick SE, Nagabhushan TL, Trotta PP, Bugg CE, J Mol Biol. 1992 Apr 20;224(4):1075-85. PMID:1569568
Page seeded by OCA on Thu Mar 20 10:28:21 2008
