1cvj

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[[Image:1cvj.gif|left|200px]]<br /><applet load="1cvj" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1cvj.gif|left|200px]]
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caption="1cvj, resolution 2.6&Aring;" />
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'''X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA'''<br />
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{{Structure
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|PDB= 1cvj |SIZE=350|CAPTION= <scene name='initialview01'>1cvj</scene>, resolution 2.6&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1CVJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=A:'>A</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVJ OCA].
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1CVJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CVJ OCA].
==Reference==
==Reference==
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Recognition of polyadenylate RNA by the poly(A)-binding protein., Deo RC, Bonanno JB, Sonenberg N, Burley SK, Cell. 1999 Sep 17;98(6):835-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10499800 10499800]
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Recognition of polyadenylate RNA by the poly(A)-binding protein., Deo RC, Bonanno JB, Sonenberg N, Burley SK, Cell. 1999 Sep 17;98(6):835-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10499800 10499800]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: rrm]]
[[Category: rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:10:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:29:24 2008''

Revision as of 08:29, 20 March 2008

Image:1cvj.gif


PDB ID 1cvj

Drag the structure with the mouse to rotate
, resolution 2.6Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA


Overview

The cocrystal structure of human poly(A)-binding protein (PABP) has been determined at 2.6 A resolution. PABP recognizes the 3' mRNA poly(A) tail and plays critical roles in eukaryotic translation initiation and mRNA stabilization/degradation. The minimal PABP used in this study consists of the N-terminal two RRM-type RNA-binding domains connected by a short linker (RRM1/2). These two RRMs form a continuous RNA-binding trough, lined by an antiparallel beta sheet backed by four alpha helices. The polyadenylate RNA adopts an extended conformation running the length of the molecular trough. Adenine recognition is primarily mediated by contacts with conserved residues found in the RNP motifs of the two RRMs. The convex dorsum of RRM1/2 displays a phylogenetically conserved hydrophobic/acidic portion, which may interact with translation initiation factors and regulatory proteins.

About this Structure

1CVJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Recognition of polyadenylate RNA by the poly(A)-binding protein., Deo RC, Bonanno JB, Sonenberg N, Burley SK, Cell. 1999 Sep 17;98(6):835-45. PMID:10499800

Page seeded by OCA on Thu Mar 20 10:29:24 2008

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