1d2s
From Proteopedia
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| - | [[Image:1d2s.gif|left|200px]] | + | [[Image:1d2s.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE''' | + | {{Structure |
| + | |PDB= 1d2s |SIZE=350|CAPTION= <scene name='initialview01'>1d2s</scene>, resolution 1.55Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=DHT:DIHYDROTESTOSTERONE'>DHT</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1D2S is a [ | + | 1D2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1D2S with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb92_1.html Anabolic Steroids]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2S OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain., Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YA, EMBO J. 2000 Feb 15;19(4):504-12. PMID:[http:// | + | Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain., Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YA, EMBO J. 2000 Feb 15;19(4):504-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10675319 10675319] |
[[Category: Anabolic Steroids]] | [[Category: Anabolic Steroids]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: steroid transport]] | [[Category: steroid transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:32:04 2008'' |
Revision as of 08:32, 20 March 2008
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| , resolution 1.55Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE
Overview
Human sex hormone-binding globulin (SHBG) transports sex steroids in blood and regulates their access to target tissues. In biological fluids, SHBG exists as a homodimer and each monomer comprises two laminin G-like domains (G domains). The crystal structure of the N-terminal G domain of SHBG in complex with 5alpha-dihydrotestosterone at 1.55 A resolution reveals both the architecture of the steroid-binding site and the quaternary structure of the dimer. We also show that G domains have jellyroll topology and are structurally related to pentraxin. In each SHBG monomer, the steroid intercalates into a hydrophobic pocket within the beta-sheet sandwich. The steroid and a 20 A distant calcium ion are not located at the dimer interface. Instead, two separate steroid-binding pockets and calcium-binding sites exist per dimer. The structure displays intriguing disorder for loop segment Pro130-Arg135. In all other jellyroll proteins, this loop is well ordered. If modelled accordingly, it covers the steroid-binding site and could thereby regulate access of ligands to the binding pocket.
About this Structure
1D2S is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1D2S with [Anabolic Steroids]. Full crystallographic information is available from OCA.
Reference
Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain., Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YA, EMBO J. 2000 Feb 15;19(4):504-12. PMID:10675319
Page seeded by OCA on Thu Mar 20 10:32:04 2008
