1hfd

From Proteopedia

Revision as of 13:30, 30 October 2007

HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM

Overview

Factor D is a serine protease essential for the activation of the, alternative pathway of complement. The structures of native factor D and a, complex formed with isatoic anhydride inhibitor were determined at, resolution of 2.3 and 1.5 A, respectively, in an isomorphous monoclinic, crystal form containing one molecule per asymmetric unit. The native, structure was compared with structures determined previously in a, triclinic cell containing two molecules with different active site, conformations. The current structure shows greater similarity with, molecule B in the triclinic cell, suggesting that this may be the dominant, factor D conformation in solution. The major conformational differences, with molecule A in the triclinic cell are located in four regions, three, of which are close ... [(full description)]

About this Structure

1HFD is a [Single protein] structure of sequence from [Homo sapiens]. Active as [Complement factor D], with EC number [3.4.21.46]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].

Reference

Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity., Jing H, Babu YS, Moore D, Kilpatrick JM, Liu XY, Volanakis JE, Narayana SV, J Mol Biol. 1998 Oct 9;282(5):1061-81. PMID:9753554

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