1d7p
From Proteopedia
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| - | [[Image:1d7p.gif|left|200px]] | + | [[Image:1d7p.gif|left|200px]] |
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| - | '''Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A''' | + | {{Structure |
| + | |PDB= 1d7p |SIZE=350|CAPTION= <scene name='initialview01'>1d7p</scene>, resolution 1.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1D7P is a [ | + | 1D7P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7P OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the C2 domain of human factor VIII at 1.5 A resolution., Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL, Nature. 1999 Nov 25;402(6760):439-42. PMID:[http:// | + | Structure of the C2 domain of human factor VIII at 1.5 A resolution., Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL, Nature. 1999 Nov 25;402(6760):439-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10586887 10586887] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: blood clotting]] | [[Category: blood clotting]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:34:03 2008'' |
Revision as of 08:34, 20 March 2008
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| , resolution 1.5Å | |||||||
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| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A
Contents |
Overview
Human factor VIII is a plasma glycoprotein that has a critical role in blood coagulation. Factor VIII circulates as a complex with von Willebrand factor. After cleavage by thrombin, factor VIIIa associates with factor IXa at the surface of activated platelets or endothelial cells. This complex activates factor X (refs 6, 7), which in turn converts prothrombin to thrombin in the presence of factor Va (refs 8, 9). The carboxyl-terminal C2 domain of factor VIII contains sites that are essential for its binding to von Willebrand factor and to negatively charged phospholipid surfaces. Here we report the structure of human factor VIII C2 domain at 1.5 A resolution. The structure reveals a beta-sandwich core, from which two beta-turns and a loop display a group of solvent-exposed hydrophobic residues. Behind the hydrophobic surface lies a ring of positively charged residues. This motif suggests a mechanism for membrane binding involving both hydrophobic and electrostatic interactions. The structure explains, in part, mutations in the C2 region of factor VIII that lead to bleeding disorders in haemophilia A.
Disease
Known diseases associated with this structure: Hemophilia A OMIM:[306700]
About this Structure
1D7P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the C2 domain of human factor VIII at 1.5 A resolution., Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL, Nature. 1999 Nov 25;402(6760):439-42. PMID:10586887
Page seeded by OCA on Thu Mar 20 10:34:03 2008
Categories: Homo sapiens | Single protein | Pratt, K P. | Shen, B W. | Stoddard, B L. | CYS | GOL | SO4 | Beta sandwich | Blood clotting
