1dg2
From Proteopedia
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| - | [[Image:1dg2.gif|left|200px]] | + | [[Image:1dg2.gif|left|200px]] |
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| - | '''SOLUTION CONFORMATION OF A-CONOTOXIN AUIB''' | + | {{Structure |
| + | |PDB= 1dg2 |SIZE=350|CAPTION= <scene name='initialview01'>1dg2</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''SOLUTION CONFORMATION OF A-CONOTOXIN AUIB''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DG2 is a [ | + | 1DG2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_aulicus Conus aulicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG2 OCA]. |
==Reference== | ==Reference== | ||
| - | Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist., Cho JH, Mok KH, Olivera BM, McIntosh JM, Park KH, Han KH, J Biol Chem. 2000 Mar 24;275(12):8680-5. PMID:[http:// | + | Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist., Cho JH, Mok KH, Olivera BM, McIntosh JM, Park KH, Han KH, J Biol Chem. 2000 Mar 24;275(12):8680-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10722709 10722709] |
[[Category: Conus aulicus]] | [[Category: Conus aulicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: two disulfide bonds and c-term amidation]] | [[Category: two disulfide bonds and c-term amidation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:37:59 2008'' |
Revision as of 08:38, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION CONFORMATION OF A-CONOTOXIN AUIB
Overview
The neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of alpha and beta subunits. alpha-Conotoxins are a homologous series of small peptides that antagonize these receptors. We present the three-dimensional solution structure of alpha-conotoxin AuIB, the first 15-residue alpha-conotoxin known to selectively block the alpha(3)beta(4) nicotinic acetylcholine receptor subtype. The pairwise backbone and heavy-atom root mean square deviation for an ensemble of 20 structures are 0.269 and 0.720 A, respectively. The overall fold of alpha-conotoxin AuIB closely resembles that of the alpha4/7 subfamily alpha-conotoxins. However, the absence of Tyr(15), normally present in other alpha4/7 members, results in tight bending of the backbone at the C terminus and effectively renders Asp(14) to assume the spatial location of Tyr(15) present in other neuronal alpha4/7 alpha-conotoxins. Structural comparison of alpha-conotoxin AuIB with the alpha(3)beta(2) subtype-specific alpha-conotoxin MII shows different electrostatic surface charge distributions, which may be important in differential receptor subtype recognition.
About this Structure
1DG2 is a Single protein structure of sequence from Conus aulicus. Full crystallographic information is available from OCA.
Reference
Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist., Cho JH, Mok KH, Olivera BM, McIntosh JM, Park KH, Han KH, J Biol Chem. 2000 Mar 24;275(12):8680-5. PMID:10722709
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