1dn6
From Proteopedia
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| - | [[Image:1dn6.gif|left|200px]] | + | [[Image:1dn6.gif|left|200px]] |
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| - | '''THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA''' | + | {{Structure |
| + | |PDB= 1dn6 |SIZE=350|CAPTION= <scene name='initialview01'>1dn6</scene>, resolution 3.000Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DN6 is a [ | + | 1DN6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DN6 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA., McCall M, Brown T, Hunter WN, Kennard O, Nature. 1986 Aug 14-20;322(6080):661-4. PMID:[http:// | + | The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA., McCall M, Brown T, Hunter WN, Kennard O, Nature. 1986 Aug 14-20;322(6080):661-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3748146 3748146] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Brown, T.]] | [[Category: Brown, T.]] | ||
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[[Category: double helix]] | [[Category: double helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:41:07 2008'' |
Revision as of 08:41, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA
Overview
Most genes in higher organisms are activated by the binding of proteins called transcription factors. One such protein, transcription factor IIIA (TFIIIA) from the frog, activates the gene for 5S RNA by binding to the region of the gene between nucleotides 45 and 97. This binding site has been defined by a variety of biochemical studies, including base-deletion experiments and DNase I footprinting. The protein also binds to the gene product: in immature frogs it is stored as a complex with 5S RNA. From the observation that TFIIIA can bind to either double-helical DNA or RNA, and from their own measurements, Rhodes and Klug have proposed that the DNA-binding site for TFIIIA has an RNA-like structure. Here we present the crystal structure analysis of a part of the DNA-binding site (nucleotides 81-89 of the gene) which forms a particularly strong interaction with the protein, and show that it has a conformation similar to the A' form of double-helical RNA.
About this Structure
1DN6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA., McCall M, Brown T, Hunter WN, Kennard O, Nature. 1986 Aug 14-20;322(6080):661-4. PMID:3748146
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