1h22
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1h22]] is a 1 chain structure | + | [[1h22]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H22 OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:012517147</ref><ref group="xtra">PMID:010934357 | + | <ref group="xtra">PMID:012517147</ref><ref group="xtra">PMID:010934357</ref><references group="xtra"/> |
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Torpedo californica]] | [[Category: Torpedo californica]] | ||
Revision as of 13:38, 20 October 2012
Contents |
STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(10)-HUPYRIDONE AT 2.15A RESOLUTION
Template:ABSTRACT PUBMED 12517147
About this Structure
1h22 is a 1 chain structure with sequence from Torpedo californica. Full crystallographic information is available from OCA.
See Also
- AChE bivalent inhibitors
- Acetylcholinesterase
- Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor
- User:Dawn M. Wong
Reference
- Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 2003 Jan 15;125(2):363-73. PMID:12517147 doi:http://dx.doi.org/10.1021/ja021111w
- Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP. Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1. Angew Chem Int Ed Engl. 2000 May 15;39(10):1775-1777. PMID:10934357
Categories: Acetylcholinesterase | Torpedo californica | Carlier, P R. | Greenblatt, H M. | Han, Y F. | Pang, Y P. | Silman, I. | Sussman, J L. | Wong, D M. | Alzheimer's disease | Bivalent ligand | Dual-site binding | Glycoprotein | Gpi-anchor neurotransmitter degradation | Huperzine some | Hydrolase | Inhibitor | Membrane | Muscle | Nerve | Neurotransmitter cleavage | Serine esterase synapse | Serine hydrolase
