1wao
From Proteopedia
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Revision as of 14:25, 30 October 2007
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PP5 STRUCTURE
Overview
Protein phosphatase 5 (Ppp5) is a serine/threonine protein phosphatase, comprising a regulatory tetratricopeptide repeat (TPR) domain N-terminal, to its phosphatase domain. Ppp5 functions in signalling pathways that, control cellular responses to stress, glucocorticoids and DNA damage. Its, phosphatase activity is suppressed by an autoinhibited conformation, maintained by the TPR domain and a C-terminal subdomain. By interacting, with the TPR domain, heat shock protein 90 (Hsp90) and fatty acids, including arachidonic acid stimulate phosphatase activity. Here, we, describe the structure of the autoinhibited state of Ppp5, revealing, mechanisms of TPR-mediated phosphatase inhibition and Hsp90- and, arachidonic acid-induced stimulation of phosphatase activity. The TPR, domain engages with ... [(full description)]
About this Structure
1WAO is a [Single protein] structure of sequence from [Homo sapiens] with MN as [ligand]. Active as [Phosphoprotein phosphatase], with EC number [3.1.3.16]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5., Yang J, Roe SM, Cliff MJ, Williams MA, Ladbury JE, Cohen PT, Barford D, EMBO J. 2005 Jan 12;24(1):1-10. Epub 2004 Dec 2. PMID:15577939
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