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1elu

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[[Image:1elu.gif|left|200px]]<br /><applet load="1elu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1elu.gif|left|200px]]
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caption="1elu, resolution 1.55&Aring;" />
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'''COMPLEX BETWEEN THE CYSTINE C-S LYASE C-DES AND ITS REACTION PRODUCT CYSTEINE PERSULFIDE.'''<br />
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{{Structure
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|PDB= 1elu |SIZE=350|CAPTION= <scene name='initialview01'>1elu</scene>, resolution 1.55&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PDA:2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-PROPIONIC+ACID'>PDA</scene> and <scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''COMPLEX BETWEEN THE CYSTINE C-S LYASE C-DES AND ITS REACTION PRODUCT CYSTEINE PERSULFIDE.'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ELU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=PDA:'>PDA</scene> and <scene name='pdbligand=CSS:'>CSS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ELU OCA].
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1ELU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ELU OCA].
==Reference==
==Reference==
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Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis., Clausen T, Kaiser JT, Steegborn C, Huber R, Kessler D, Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3856-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10760256 10760256]
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Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis., Clausen T, Kaiser JT, Steegborn C, Huber R, Kessler D, Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3856-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10760256 10760256]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Synechocystis sp.]]
[[Category: Synechocystis sp.]]
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[[Category: thiocysteine]]
[[Category: thiocysteine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:29:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:57:19 2008''

Revision as of 08:57, 20 March 2008

Image:1elu.gif


PDB ID 1elu

Drag the structure with the mouse to rotate
, resolution 1.55Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



COMPLEX BETWEEN THE CYSTINE C-S LYASE C-DES AND ITS REACTION PRODUCT CYSTEINE PERSULFIDE.


Overview

FeS clusters are versatile cofactors of a variety of proteins, but the mechanisms of their biosynthesis are still unknown. The cystine C-S lyase from Synechocystis has been identified as a participant in ferredoxin FeS cluster formation. Herein, we report on the crystal structure of the lyase and of a complex with the reaction products of cystine cleavage at 1.8- and 1.55-A resolution, respectively. The sulfur-containing product was unequivocally identified as cysteine persulfide. The reactive persulfide group is fixed by a hydrogen bond to His-114 in the center of a hydrophobic pocket and is thereby shielded from the solvent. Binding and stabilization of the cysteine persulfide represent an alternative to the generation of a protein-bound persulfide by NifS-like proteins and point to the general importance of persulfidic compounds for FeS cluster assembly.

About this Structure

1ELU is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of the cystine C-S lyase from Synechocystis: stabilization of cysteine persulfide for FeS cluster biosynthesis., Clausen T, Kaiser JT, Steegborn C, Huber R, Kessler D, Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3856-61. PMID:10760256

Page seeded by OCA on Thu Mar 20 10:57:19 2008

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