1esf
From Proteopedia
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| - | [[Image:1esf.gif|left|200px]] | + | [[Image:1esf.gif|left|200px]] |
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| - | '''STAPHYLOCOCCAL ENTEROTOXIN A''' | + | {{Structure |
| + | |PDB= 1esf |SIZE=350|CAPTION= <scene name='initialview01'>1esf</scene>, resolution 1.9Å | ||
| + | |SITE= <scene name='pdbsite=CD1:Cd+2++Binding+Site+I'>CD1</scene> and <scene name='pdbsite=CD2:Cd+2++Binding+Site+II'>CD2</scene> | ||
| + | |LIGAND= <scene name='pdbligand=CD:CADMIUM ION'>CD</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STAPHYLOCOCCAL ENTEROTOXIN A''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ESF is a [ | + | 1ESF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESF OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J. 1995 Jul 17;14(14):3292-301. PMID:[http:// | + | Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J. 1995 Jul 17;14(14):3292-301. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7628431 7628431] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
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[[Category: CD]] | [[Category: CD]] | ||
[[Category: enterotoxin]] | [[Category: enterotoxin]] | ||
| - | [[Category: staphylococcal enterotoxin type | + | [[Category: staphylococcal enterotoxin type some]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:59:41 2008'' |
Revision as of 08:59, 20 March 2008
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| , resolution 1.9Å | |||||||
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| Sites: | and | ||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
STAPHYLOCOCCAL ENTEROTOXIN A
Overview
Staphylococcal enterotoxins are prototype superantigens characterized by their ability to bind to major histocompatibility complex (MHC) class II molecules and subsequently activate a large fraction of T-lymphocytes. The crystal structure of staphylococcal enterotoxin type A (SEA), a 27 kDa monomeric protein, was determined to 1.9 A resolution with an R-factor of 19.9% by multiple isomorphous replacement. SEA is a two domain protein composed of a beta-barrel and a beta-grasp motif demonstrating the same general structure as staphylococcal enterotoxins SEB and TSST-1. Unique for SEA, however, is a Zn2+ coordination site involved in MHC class II binding. Four amino acids including Ser1, His187, His225 and Asp227 were found to be involved in direct coordination of the metal ion. SEA is the first Zn2+ binding enterotoxin that has been structurally determined.
About this Structure
1ESF is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the superantigen staphylococcal enterotoxin type A., Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA, EMBO J. 1995 Jul 17;14(14):3292-301. PMID:7628431
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