1ete

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[[Image:1ete.gif|left|200px]]<br /><applet load="1ete" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ete.gif|left|200px]]
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caption="1ete, resolution 2.2&Aring;" />
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'''CRYSTAL STRUCTURE OF THE FLT3 LIGAND'''<br />
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{{Structure
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|PDB= 1ete |SIZE=350|CAPTION= <scene name='initialview01'>1ete</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE FLT3 LIGAND'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ETE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ETE OCA].
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1ETE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ETE OCA].
==Reference==
==Reference==
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Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots., Savvides SN, Boone T, Andrew Karplus P, Nat Struct Biol. 2000 Jun;7(6):486-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10881197 10881197]
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Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots., Savvides SN, Boone T, Andrew Karplus P, Nat Struct Biol. 2000 Jun;7(6):486-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10881197 10881197]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: four-helix bundle]]
[[Category: four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:31:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:00:02 2008''

Revision as of 09:00, 20 March 2008

Image:1ete.gif


PDB ID 1ete

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE FLT3 LIGAND


Overview

Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles. Comparisons of structure-function relationships of Flt3L with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and stem cell factor (SCF) suggest that they have a common receptor binding mode that is distinct from the paradigm derived from the complex of growth hormone with its receptor. Furthermore, we identify recognition features common to all helical and cystine-knot protein ligands that activate type III tyrosine kinase receptors, and the closely related type V tyrosine kinase receptors.

About this Structure

1ETE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots., Savvides SN, Boone T, Andrew Karplus P, Nat Struct Biol. 2000 Jun;7(6):486-91. PMID:10881197

Page seeded by OCA on Thu Mar 20 11:00:02 2008

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