1fd0

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[[Image:1fd0.gif|left|200px]]<br /><applet load="1fd0" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fd0.gif|left|200px]]
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caption="1fd0, resolution 1.38&Aring;" />
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'''ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254'''<br />
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{{Structure
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|PDB= 1fd0 |SIZE=350|CAPTION= <scene name='initialview01'>1fd0</scene>, resolution 1.38&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=254:6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALEN-2-YL)-METHYL]-NAPHTALENE-2-CARBOXYLIC+ACID'>254</scene> and <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FD0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=254:'>254</scene> and <scene name='pdbligand=LMU:'>LMU</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FD0 OCA].
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1FD0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FD0 OCA].
==Reference==
==Reference==
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C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity., Klaholz B, Moras D, Structure. 2002 Sep;10(9):1197-204. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12220491 12220491]
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C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity., Klaholz B, Moras D, Structure. 2002 Sep;10(9):1197-204. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12220491 12220491]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: drug design]]
[[Category: drug design]]
[[Category: isotype selectivity]]
[[Category: isotype selectivity]]
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[[Category: retinoid ligand complexes]]
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[[Category: retinoid ligand complex]]
[[Category: spine]]
[[Category: spine]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: structural proteomics in europe]]
[[Category: structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:37:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:07:33 2008''

Revision as of 09:07, 20 March 2008

Image:1fd0.gif


PDB ID 1fd0

Drag the structure with the mouse to rotate
, resolution 1.38Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254


Overview

Hydrogen bonds between polarized atoms play a crucial role in protein interactions and are often used in drug design, which usually neglects the potential of C-H...O hydrogen bonds. The 1.4 A resolution crystal structure of the ligand binding domain of the retinoic acid receptor RARgamma complexed with the retinoid SR11254 reveals several types of C-H...O hydrogen bonds. A striking example is the hydroxyl group of the ligand that acts as an H bond donor and acceptor, leading to a synergy between classical and C-H...O hydrogen bonds. This interaction introduces both specificity and affinity within the hydrophobic ligand pocket. The similarity of intraprotein and protein-ligand C-H...O interactions suggests that such bonds should be considered in rational drug design approaches.

About this Structure

1FD0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity., Klaholz B, Moras D, Structure. 2002 Sep;10(9):1197-204. PMID:12220491

Page seeded by OCA on Thu Mar 20 11:07:33 2008

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