1fmk

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[[Image:1fmk.gif|left|200px]]<br /><applet load="1fmk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fmk.gif|left|200px]]
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caption="1fmk, resolution 1.5&Aring;" />
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'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC'''<br />
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{{Structure
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|PDB= 1fmk |SIZE=350|CAPTION= <scene name='initialview01'>1fmk</scene>, resolution 1.5&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FMK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMK OCA].
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1FMK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMK OCA].
==Reference==
==Reference==
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Three-dimensional structure of the tyrosine kinase c-Src., Xu W, Harrison SC, Eck MJ, Nature. 1997 Feb 13;385(6617):595-602. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9024657 9024657]
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Three-dimensional structure of the tyrosine kinase c-Src., Xu W, Harrison SC, Eck MJ, Nature. 1997 Feb 13;385(6617):595-602. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9024657 9024657]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tyrosine kinase]]
[[Category: tyrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:11:04 2008''

Revision as of 09:11, 20 March 2008

Image:1fmk.gif


PDB ID 1fmk

Drag the structure with the mouse to rotate
, resolution 1.5Å
Activity: Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC


Contents

Overview

The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tall, has been determined at 1.7 A resolution in a closed, inactive state. Interactions among domains, stabilized by binding of the phosphorylated tail to the SH2 domain, lock the molecule in a conformation that simultaneously disrupts the kinase active site and sequesters the binding surfaces of the SH2 and SH3 domains. The structure shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase.

Disease

Known disease associated with this structure: Colon cancer, advanced OMIM:[190090]

About this Structure

1FMK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the tyrosine kinase c-Src., Xu W, Harrison SC, Eck MJ, Nature. 1997 Feb 13;385(6617):595-602. PMID:9024657

Page seeded by OCA on Thu Mar 20 11:11:04 2008

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