1fml

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[[Image:1fml.gif|left|200px]]<br /><applet load="1fml" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fml.gif|left|200px]]
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caption="1fml, resolution 2.75&Aring;" />
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'''CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP'''<br />
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{{Structure
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|PDB= 1fml |SIZE=350|CAPTION= <scene name='initialview01'>1fml</scene>, resolution 2.75&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=A3P:ADENOSINE-3'-5'-DIPHOSPHATE'>A3P</scene> and <scene name='pdbligand=RTL:RETINOL'>RTL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FML is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=A3P:'>A3P</scene> and <scene name='pdbligand=RTL:'>RTL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FML OCA].
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1FML is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FML OCA].
==Reference==
==Reference==
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A helical lid converts a sulfotransferase to a dehydratase., Pakhomova S, Kobayashi M, Buck J, Newcomer ME, Nat Struct Biol. 2001 May;8(5):447-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11323722 11323722]
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A helical lid converts a sulfotransferase to a dehydratase., Pakhomova S, Kobayashi M, Buck J, Newcomer ME, Nat Struct Biol. 2001 May;8(5):447-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11323722 11323722]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Spodoptera frugiperda]]
[[Category: Spodoptera frugiperda]]
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[[Category: RTL]]
[[Category: RTL]]
[[Category: 5'-diphosphate]]
[[Category: 5'-diphosphate]]
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[[Category: adenosine 3']]
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[[Category: adenosine 3s']]
[[Category: dehydratase]]
[[Category: dehydratase]]
[[Category: retinol]]
[[Category: retinol]]
[[Category: sulfotransferase]]
[[Category: sulfotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:11:08 2008''

Revision as of 09:11, 20 March 2008

Image:1fml.gif


PDB ID 1fml

Drag the structure with the mouse to rotate
, resolution 2.75Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP


Overview

We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase.

About this Structure

1FML is a Single protein structure of sequence from Spodoptera frugiperda. Full crystallographic information is available from OCA.

Reference

A helical lid converts a sulfotransferase to a dehydratase., Pakhomova S, Kobayashi M, Buck J, Newcomer ME, Nat Struct Biol. 2001 May;8(5):447-51. PMID:11323722

Page seeded by OCA on Thu Mar 20 11:11:08 2008

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