1frt
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1frt.gif|left|200px]] | + | [[Image:1frt.gif|left|200px]] |
| - | + | ||
| - | '''CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC''' | + | {{Structure |
| + | |PDB= 1frt |SIZE=350|CAPTION= <scene name='initialview01'>1frt</scene>, resolution 4.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= BETA-2-MICROGLOBULIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1FRT is a [ | + | 1FRT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FRT OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the complex of rat neonatal Fc receptor with Fc., Burmeister WP, Huber AH, Bjorkman PJ, Nature. 1994 Nov 24;372(6504):379-83. PMID:[http:// | + | Crystal structure of the complex of rat neonatal Fc receptor with Fc., Burmeister WP, Huber AH, Bjorkman PJ, Nature. 1994 Nov 24;372(6504):379-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7969498 7969498] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| Line 18: | Line 27: | ||
[[Category: complex (receptor/immunoglobulin)]] | [[Category: complex (receptor/immunoglobulin)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:13:08 2008'' |
Revision as of 09:13, 20 March 2008
| |||||||
| , resolution 4.5Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | BETA-2-MICROGLOBULIN (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC
Overview
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the bloodstream of the newborn. FcRn is structurally similar to class I major histocompatibility complex (MHC) molecules, despite differences in the ligands they bind (the Fc portion of IgG and antigenic peptides, respectively). A low-resolution crystal structure of the complex between FcRn and Fc localizes the binding site for Fc to the side of FcRn, distinct from the tops of the alpha 1 and alpha 2 domains which serve as the peptide and T-cell receptor binding sites in class I molecules. FcRn binds to Fc at the interface between the Fc CH2 and CH3 domains, which contains several histidine residues that could account for the sharply pH-dependent FcRn/IgG interaction. A dimer of FcRn heterodimers observed in the co-crystals and in the crystals of FcRn alone could be involved in binding Fc, correlating with the 2:1 binding stoichiometry between FcRn and IgG (ref. 4) and suggesting an unusual orientation of FcRn on the membrane.
About this Structure
1FRT is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the complex of rat neonatal Fc receptor with Fc., Burmeister WP, Huber AH, Bjorkman PJ, Nature. 1994 Nov 24;372(6504):379-83. PMID:7969498
Page seeded by OCA on Thu Mar 20 11:13:08 2008
