1t4v

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Revision as of 01:59, 27 July 2012

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Template:STRUCTURE 1t4v

Contents 1 Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin 2 About this Structure 3 See Also 4 Reference

Crystal Structure Analysis of a novel Oxyguanidine bound to Thrombin

Template:ABSTRACT PUBMED 15203151

About this Structure

1t4v is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Hirudin
• Thrombin

Reference

• Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31. PMID:15203151 doi:http://dx.doi.org/10.1016/j.bmcl.2004.05.002