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1g3j
From Proteopedia
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| - | [[Image:1g3j.gif|left|200px]] | + | [[Image:1g3j.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX''' | + | {{Structure |
| + | |PDB= 1g3j |SIZE=350|CAPTION= <scene name='initialview01'>1g3j</scene>, resolution 2.1Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1G3J is a [ | + | 1G3J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3J OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:[http:// | + | Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11136974 11136974] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: tcf-3]] | [[Category: tcf-3]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:17:42 2008'' |
Revision as of 09:17, 20 March 2008
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| , resolution 2.1Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX
Contents |
Overview
The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.
Disease
Known diseases associated with this structure: Colorectal cancer OMIM:[116806], Hepatoblastoma OMIM:[116806], Hepatocellular carcinoma OMIM:[116806], Ovarian carcinoma, endometrioid type OMIM:[116806], Pilomatricoma OMIM:[116806]
About this Structure
1G3J is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:11136974
Page seeded by OCA on Thu Mar 20 11:17:42 2008
