1g62

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1g62.gif|left|200px]]<br /><applet load="1g62" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1g62.gif|left|200px]]
-
caption="1g62, resolution 2.5&Aring;" />
+
 
-
'''CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6'''<br />
+
{{Structure
 +
|PDB= 1g62 |SIZE=350|CAPTION= <scene name='initialview01'>1g62</scene>, resolution 2.5&Aring;
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY=
 +
|GENE= TIF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
 +
}}
 +
 
 +
'''CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1G62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G62 OCA].
+
1G62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G62 OCA].
==Reference==
==Reference==
-
Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11101899 11101899]
+
Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101899 11101899]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 23: Line 32:
[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
-
[[Category: structural genomics]]
+
[[Category: structural genomic]]
[[Category: subdomain]]
[[Category: subdomain]]
[[Category: velcro closure]]
[[Category: velcro closure]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:46:31 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:18:42 2008''

Revision as of 09:18, 20 March 2008

Image:1g62.gif


PDB ID 1g62

Drag the structure with the mouse to rotate
, resolution 2.5Å
Gene: TIF6 (Saccharomyces cerevisiae)
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6


Overview

Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.

About this Structure

1G62 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899

Page seeded by OCA on Thu Mar 20 11:18:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g62"
Personal tools