3e51

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Revision as of 04:59, 27 July 2012

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Template:STRUCTURE 3e51

Contents 1 Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor

Template:ABSTRACT PUBMED 18796353

About this Structure

3e51 is a 2 chain structure of RNA polymerase with sequence from Viruses. Full crystallographic information is available from OCA.

See Also

• RNA polymerase

Reference

• Dragovich PS, Blazel JK, Ellis DA, Han Q, Kamran R, Kissinger CR, LeBrun LA, Li LS, Murphy DE, Noble M, Patel RA, Ruebsam F, Sergeeva MV, Shah AM, Showalter RE, Tran CV, Tsan M, Webber SE, Kirkovsky L, Zhou Y. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5635-9. Epub 2008 Aug 29. PMID:18796353 doi:10.1016/j.bmcl.2008.08.094