1g7r

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[[Image:1g7r.jpg|left|200px]]<br /><applet load="1g7r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1g7r.jpg|left|200px]]
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caption="1g7r, resolution 2.2&Aring;" />
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'''X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B'''<br />
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{{Structure
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|PDB= 1g7r |SIZE=350|CAPTION= <scene name='initialview01'>1g7r</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1G7R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G7R OCA].
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1G7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G7R OCA].
==Reference==
==Reference==
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X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding., Roll-Mecak A, Cao C, Dever TE, Burley SK, Cell. 2000 Nov 22;103(5):781-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11114334 11114334]
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X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding., Roll-Mecak A, Cao C, Dever TE, Burley SK, Cell. 2000 Nov 22;103(5):781-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11114334 11114334]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: translational gtpase]]
[[Category: translational gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:47:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:19:25 2008''

Revision as of 09:19, 20 March 2008

Image:1g7r.jpg


PDB ID 1g7r

Drag the structure with the mouse to rotate
, resolution 2.2Å
Coordinates: save as pdb, mmCIF, xml



X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B


Overview

X-ray structures of the universal translation initiation factor IF2/eIF5B have been determined in three states: free enzyme, inactive IF2/eIF5B.GDP, and active IF2/eIF5B.GTP. The "chalice-shaped" enzyme is a GTPase that facilitates ribosomal subunit joining and Met-tRNA(i) binding to ribosomes in all three kingdoms of life. The conserved core of IF2/eIF5B consists of an N-terminal G domain (I) plus an EF-Tu-type beta barrel (II), followed by a novel alpha/beta/alpha-sandwich (III) connected via an alpha helix to a second EF-Tu-type beta barrel (IV). Structural comparisons reveal a molecular lever, which amplifies a modest conformational change in the Switch 2 region of the G domain induced by Mg(2+)/GTP binding over a distance of 90 A from the G domain active center to domain IV. Mechanisms of GTPase function and ribosome binding are discussed.

About this Structure

1G7R is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding., Roll-Mecak A, Cao C, Dever TE, Burley SK, Cell. 2000 Nov 22;103(5):781-92. PMID:11114334

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