This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1gea
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1gea.gif|left|200px]] | + | [[Image:1gea.gif|left|200px]] |
| - | + | ||
| - | '''RECEPTOR-BOUND CONFORMATION OF PACAP21''' | + | {{Structure |
| + | |PDB= 1gea |SIZE=350|CAPTION= <scene name='initialview01'>1gea</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''RECEPTOR-BOUND CONFORMATION OF PACAP21''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GEA is a [ | + | 1GEA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEA OCA]. |
==Reference== | ==Reference== | ||
| - | Conformation of a peptide ligand bound to its G-protein coupled receptor., Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M, Nat Struct Biol. 2001 Feb;8(2):161-5. PMID:[http:// | + | Conformation of a peptide ligand bound to its G-protein coupled receptor., Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M, Nat Struct Biol. 2001 Feb;8(2):161-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11175907 11175907] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Endo, S.]] | [[Category: Endo, S.]] | ||
| Line 23: | Line 32: | ||
[[Category: Shirakawa, M.]] | [[Category: Shirakawa, M.]] | ||
[[Category: beta coil]] | [[Category: beta coil]] | ||
| - | [[Category: consecutive beta | + | [[Category: consecutive beta turn]] |
[[Category: helix]] | [[Category: helix]] | ||
[[Category: type-i beta turn]] | [[Category: type-i beta turn]] | ||
[[Category: type-ii beta turn]] | [[Category: type-ii beta turn]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:21:53 2008'' |
Revision as of 09:21, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RECEPTOR-BOUND CONFORMATION OF PACAP21
Overview
Many peptide hormones elicit a wide array of physiological effects by binding to G-protein coupled receptors. We have determined the conformation of pituitary adenylate cyclase activating polypeptide, PACAP(1--21)NH(2), bound to a PACAP-specific receptor by NMR spectroscopy. Residues 3--7 form a unique beta-coil structure that is preceded by an N-terminal extended tail. This beta-coil creates a patch of hydrophobic residues that is important for receptor binding. In contrast, the C-terminal region (residues 8--21) forms an alpha-helix, similar to that in the micelle-bound PACAP. Thus, the conformational difference between PACAP in the receptor-bound and the micelle-bound states is limited to the N-terminal seven residues. This observation is consistent with the two-step ligand transportation model in which PACAP first binds to the membrane nonspecifically and then diffuses two-dimensionally in search of its receptor; a conformational change at the N-terminal region then allows specific interactions between the ligand and the receptor.
About this Structure
1GEA is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Conformation of a peptide ligand bound to its G-protein coupled receptor., Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M, Nat Struct Biol. 2001 Feb;8(2):161-5. PMID:11175907
Page seeded by OCA on Thu Mar 20 11:21:53 2008
