1vr1

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Revision as of 07:30, 27 July 2012

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Template:STRUCTURE 1vr1

Contents 1 Specifity for Plasminogen Activator Inhibitor-1 2 About this Structure 3 See Also 4 Reference

Specifity for Plasminogen Activator Inhibitor-1

Template:ABSTRACT PUBMED 10543954

About this Structure

1vr1 is a 3 chain structure of Hirudin and Thrombin with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Hirudin
• Thrombin

Reference

• Dekker RJ, Eichinger A, Stoop AA, Bode W, Pannekoek H, Horrevoets AJ. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. PMID:10543954 doi:10.1006/jmbi.1999.3178