1gl9
From Proteopedia
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| - | [[Image:1gl9.gif|left|200px]] | + | [[Image:1gl9.gif|left|200px]] |
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| - | '''ARCHAEOGLOBUS FULGIDUS REVERSE GYRASE COMPLEXED WITH ADPNP''' | + | {{Structure |
| + | |PDB= 1gl9 |SIZE=350|CAPTION= <scene name='initialview01'>1gl9</scene>, resolution 3.2Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+C'>AC1</scene> | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''ARCHAEOGLOBUS FULGIDUS REVERSE GYRASE COMPLEXED WITH ADPNP''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GL9 is a [ | + | 1GL9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GL9 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA., Rodriguez AC, Stock D, EMBO J. 2002 Feb 1;21(3):418-26. PMID:[http:// | + | Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA., Rodriguez AC, Stock D, EMBO J. 2002 Feb 1;21(3):418-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11823434 11823434] |
[[Category: Archaeoglobus fulgidus]] | [[Category: Archaeoglobus fulgidus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: topoisomerase]] | [[Category: topoisomerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:24:41 2008'' |
Revision as of 09:24, 20 March 2008
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| , resolution 3.2Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
ARCHAEOGLOBUS FULGIDUS REVERSE GYRASE COMPLEXED WITH ADPNP
Overview
Reverse gyrase is the only topoisomerase known to positively supercoil DNA. The protein appears to be unique to hyperthermophiles, where its activity is believed to protect the genome from denaturation. The 120 kDa enzyme is the only member of the type I topoisomerase family that requires ATP, which is bound and hydrolysed by a helicase-like domain. We have determined the crystal structure of reverse gyrase from Archaeoglobus fulgidus in the presence and absence of nucleotide cofactor. The structure provides the first view of an intact supercoiling enzyme, explains mechanistic differences from other type I topoisomerases and suggests a model for how the two domains of the protein cooperate to positively supercoil DNA. Coordinates have been deposited in the Protein Data Bank under accession codes 1GKU and 1GL9.
About this Structure
1GL9 is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.
Reference
Crystal structure of reverse gyrase: insights into the positive supercoiling of DNA., Rodriguez AC, Stock D, EMBO J. 2002 Feb 1;21(3):418-26. PMID:11823434
Page seeded by OCA on Thu Mar 20 11:24:41 2008
