1gri

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[[Image:1gri.gif|left|200px]]<br /><applet load="1gri" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1gri.gif|left|200px]]
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caption="1gri, resolution 3.1&Aring;" />
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'''GRB2'''<br />
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{{Structure
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|PDB= 1gri |SIZE=350|CAPTION= <scene name='initialview01'>1gri</scene>, resolution 3.1&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= HGRB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''GRB2'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GRI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GRI OCA].
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1GRI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GRI OCA].
==Reference==
==Reference==
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Crystal structure of the mammalian Grb2 adaptor., Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A, Science. 1995 Apr 14;268(5208):291-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7716522 7716522]
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Crystal structure of the mammalian Grb2 adaptor., Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A, Science. 1995 Apr 14;268(5208):291-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7716522 7716522]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: sh3]]
[[Category: sh3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:53:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:26:57 2008''

Revision as of 09:26, 20 March 2008

Image:1gri.gif


PDB ID 1gri

Drag the structure with the mouse to rotate
, resolution 3.1Å
Gene: HGRB2 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



GRB2


Contents

Overview

The mammalian growth factor receptor-binding protein Grb2 is an adaptor that mediates activation of guanine nucleotide exchange on Ras. Grb2 binds to the receptor through its SH2 domain and to the carboxyl-terminal domain of Son of sevenless through its two SH3 domains. It is thus a key element in the signal transduction pathway. The crystal structure of Grb2 was determined to 3.1 angstrom resolution. The asymmetric unit is composed of an embedded dimer. The interlaced junctions between the SH2 and SH3 domains bring the two adjacent faces of the SH3 domains in van der Waals contact but leave room for the binding of proline-rich peptides.

Disease

Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[100790], Haddad syndrome OMIM:[100790]

About this Structure

1GRI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the mammalian Grb2 adaptor., Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A, Science. 1995 Apr 14;268(5208):291-3. PMID:7716522

Page seeded by OCA on Thu Mar 20 11:26:57 2008

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