2is0

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Revision as of 09:40, 27 July 2012

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Template:STRUCTURE 2is0

Contents 1 Crystal structure of human Beta-secretase complexed with inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal structure of human Beta-secretase complexed with inhibitor

Template:ABSTRACT PUBMED 17149856

About this Structure

2is0 is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Rajapakse HA, Nantermet PG, Selnick HG, Munshi S, McGaughey GB, Lindsley SR, Young MB, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP. Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1). J Med Chem. 2006 Dec 14;49(25):7270-3. PMID:17149856 doi:10.1021/jm061046r