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1h04

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[[Image:1h04.gif|left|200px]]<br /><applet load="1h04" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1h04.gif|left|200px]]
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caption="1h04, resolution 2.0&Aring;" />
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'''HUMAN CD55 DOMAINS 3 & 4'''<br />
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{{Structure
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|PDB= 1h04 |SIZE=350|CAPTION= <scene name='initialview01'>1h04</scene>, resolution 2.0&Aring;
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|SITE= <scene name='pdbsite=AC1:Ni+Binding+Site+For+Chain+P'>AC1</scene>
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|LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HUMAN CD55 DOMAINS 3 & 4'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1H04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ni+Binding+Site+For+Chain+P'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H04 OCA].
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1H04 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H04 OCA].
==Reference==
==Reference==
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Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12499389 12499389]
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Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12499389 12499389]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ligand for cd97]]
[[Category: ligand for cd97]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:55:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:30:22 2008''

Revision as of 09:30, 20 March 2008

Image:1h04.gif


PDB ID 1h04

Drag the structure with the mouse to rotate
, resolution 2.0Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



HUMAN CD55 DOMAINS 3 & 4


Contents

Overview

Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.

Disease

Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]

About this Structure

1H04 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389

Page seeded by OCA on Thu Mar 20 11:30:22 2008

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