2zjh

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Revision as of 11:36, 27 July 2012

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Template:STRUCTURE 2zjh

Contents 1 Crystal structure of the human BACE1 catalytic domain in complex with N-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide 2 About this Structure 3 See Also 4 Reference

Crystal structure of the human BACE1 catalytic domain in complex with N-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide

Template:ABSTRACT PUBMED 019284778

About this Structure

2zjh is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Yang W, Fucini RV, Fahr BT, Randal M, Lind KE, Lam MB, Lu W, Lu Y, Cary DR, Romanowski MJ, Colussi D, Pietrak B, Allison TJ, Munshi SK, Penny DM, Pham P, Sun J, Thomas AE, Wilkinson JM, Jacobs JW, McDowell RS, Ballinger MD. Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering. Biochemistry. 2009 Jun 2;48(21):4488-96. PMID:19284778 doi:10.1021/bi900017q