1h4u
From Proteopedia
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| - | [[Image:1h4u.gif|left|200px]] | + | [[Image:1h4u.gif|left|200px]] |
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| - | '''DOMAIN G2 OF MOUSE NIDOGEN-1''' | + | {{Structure |
| + | |PDB= 1h4u |SIZE=350|CAPTION= <scene name='initialview01'>1h4u</scene>, resolution 2.20Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''DOMAIN G2 OF MOUSE NIDOGEN-1''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1H4U is a [ | + | 1H4U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H4U OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:[http:// | + | Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11427896 11427896] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: extracellular matrix protein]] | [[Category: extracellular matrix protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:32:12 2008'' |
Revision as of 09:32, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
DOMAIN G2 OF MOUSE NIDOGEN-1
Overview
Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has unexpected similarity to green fluorescent protein. A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding.
About this Structure
1H4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896
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