2c11

From Proteopedia

Revision as of 14:49, 30 October 2007

CRYSTAL STRUCTURE OF THE 2-HYDRAZINOPYRIDINE OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE

Overview

Semicarbazide-sensitive amine oxidase (SSAO) belongs to a ubiquitous, family of copper-containing amine oxidases (CuAOs). SSAO is also known as, vascular adhesion protein-1 (VAP-1) and has been identified as one of the, adhesion molecules involved in the leukocyte-extravasation process. The, structure of a truncated soluble form of human SSAO has been solved and, refined to 2.5 A. As expected, SSAO is a homodimer with a fold typical of, the CuAO family. The topaquinone (TPQ) cofactor and a copper ion, characteristic of CuAOs are present in the active site, with the TPQ in, the active ;off-copper' conformation. The structure reveals that a leucine, residue (Leu469) located adjacent to the active site could function as a, gate controlling its accessibility. An RGD motif is displayed on the, ... [(full description)]

About this Structure

2C11 is a [Single protein] structure of sequence from [Homo sapiens] with NAG, NDG, CA, CU, CL and PAQ as [ligands]. Active as [Amine oxidase (copper-containing)], with EC number [1.4.3.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1., Jakobsson E, Nilsson J, Ogg D, Kleywegt GJ, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1550-62. Epub 2005, Oct 19. PMID:16239734

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