1h8p

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[[Image:1h8p.jpg|left|200px]]<br /><applet load="1h8p" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1h8p.jpg|left|200px]]
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caption="1h8p, resolution 1.82&Aring;" />
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'''BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE'''<br />
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{{Structure
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|PDB= 1h8p |SIZE=350|CAPTION= <scene name='initialview01'>1h8p</scene>, resolution 1.82&Aring;
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|SITE= <scene name='pdbsite=AC1:Poc+Binding+Site+For+Residue+A1111'>AC1</scene>
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|LIGAND= <scene name='pdbligand=PC:PHOSPHOCHOLINE'>PC</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1H8P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=PC:'>PC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Poc+Binding+Site+For+Residue+A1111'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8P OCA].
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1H8P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8P OCA].
==Reference==
==Reference==
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Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11937055 11937055]
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Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937055 11937055]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: phosphorylcholine-binding protein]]
[[Category: phosphorylcholine-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:58:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:33:54 2008''

Revision as of 09:33, 20 March 2008

Image:1h8p.jpg


PDB ID 1h8p

Drag the structure with the mouse to rotate
, resolution 1.82Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



BULL SEMINAL PLASMA PDC-109 FIBRONECTIN TYPE II MODULE


Overview

Bovine seminal plasma PDC-109 binds to sperm surface choline lipids and promotes sperm capacitation by stimulating the efflux of cholesterol and phospholipids. The structure of PDC-109 with bound phosphorylcholine was solved using MAD data of a single platinum site. Its two globular (40 x 50 x 20 A(3)) Fn2 domains are linked and clustered by a short polypeptide. The choline binding sites lie at the same face of the molecule. Phosphorylcholine binds to the Fn2 domains through a cation-pi interaction between the quaternary ammonium group and a core tryptophan, plus hydrogen bonding between hydroxyls of exposed tyrosines and the phosphate group. The structure of the PDC-109-oPC complex provides a structural ground for the sperm membrane-coating mechanism underlying PDC-109-induced capacitation.

About this Structure

1H8P is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex., Wah DA, Fernandez-Tornero C, Sanz L, Romero A, Calvete JJ, Structure. 2002 Apr;10(4):505-14. PMID:11937055

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