1hbx
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1hbx.gif|left|200px]] | + | [[Image:1hbx.gif|left|200px]] |
| - | + | ||
| - | '''TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA''' | + | {{Structure |
| + | |PDB= 1hbx |SIZE=350|CAPTION= <scene name='initialview01'>1hbx</scene>, resolution 3.15Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= SRF (132-223) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 10: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1HBX is a [ | + | 1HBX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HBX OCA]. |
==Reference== | ==Reference== | ||
| - | The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex., Hassler M, Richmond TJ, EMBO J. 2001 Jun 15;20(12):3018-28. PMID:[http:// | + | The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex., Hassler M, Richmond TJ, EMBO J. 2001 Jun 15;20(12):3018-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11406578 11406578] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 23: | Line 32: | ||
[[Category: transcription complex]] | [[Category: transcription complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:35:00 2008'' |
Revision as of 09:35, 20 March 2008
| |||||||
| , resolution 3.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | SRF (132-223) (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TERNARY COMPLEX OF SAP-1 AND SRF WITH SPECIFIC SRE DNA
Contents |
Overview
The serum response element (SRE) is found in several immediate-early gene promoters. This DNA sequence is necessary and sufficient for rapid transcriptional induction of the human c-fos proto-oncogene in response to stimuli external to the cell. Full activation of the SRE requires the cooperative binding of a ternary complex factor (TCF) and serum response factor (SRF) to their specific DNA sites. The X-ray structure of the human SAP-1-SRF-SRE DNA ternary complex was determined (Protein Data Bank code 1hbx). It shows SAP-1 TCF bound to SRF through interactions between the SAP-1 B-box and SRF MADS domain in addition to contacts between their respective DNA-binding motifs. The SAP-1 B-box is part of a flexible linker of which 21 amino acids become ordered upon ternary complex formation. Comparison with a similar region from the yeast MATalpha2-MCM1-DNA complex suggests a common binding motif through which MADS-box proteins may interact with additional factors such as Fli-1.
Disease
Known disease associated with this structure: Osteoarthritis of hip, female-specific, susceptibility to OMIM:[605083]
About this Structure
1HBX is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex., Hassler M, Richmond TJ, EMBO J. 2001 Jun 15;20(12):3018-28. PMID:11406578
Page seeded by OCA on Thu Mar 20 11:35:00 2008
