1t4f

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Revision as of 14:07, 27 July 2012

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Template:STRUCTURE 1t4f

Contents 1 Structure of human MDM2 in complex with an optimized p53 peptide 2 About this Structure 3 See Also 4 Reference

Structure of human MDM2 in complex with an optimized p53 peptide

Template:ABSTRACT PUBMED 15715460

About this Structure

1t4f is a 2 chain structure of MDM2 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• MDM2

Reference

• Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK, Cummings MD, LaFrance LV, Milkiewicz KL, Calvo RR, Maguire D, Lattanze J, Franks CF, Zhao S, Ramachandren K, Bylebyl GR, Zhang M, Manthey CL, Petrella EC, Pantoliano MW, Deckman IC, Spurlino JC, Maroney AC, Tomczuk BE, Molloy CJ, Bone RF. Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem. 2005 Feb 24;48(4):909-12. PMID:15715460 doi:10.1021/jm049137g